Detalhe da pesquisa
1.
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Bioorg Med Chem Lett
; 47: 128202, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34139325
2.
Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.
Bioorg Med Chem Lett
; 28(7): 1211-1218, 2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29519738
3.
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.
Bioorg Med Chem Lett
; 27(23): 5131-5138, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29100801
4.
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.
Bioorg Med Chem Lett
; 27(11): 2594-2601, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400234
5.
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I.
Bioorg Med Chem Lett
; 24(9): 2073-8, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24725435
6.
Effect of commonly used organic solvents on aldehyde oxidase-mediated vanillin, phthalazine and methotrexate oxidation in human, rat and mouse liver subcellular fractions.
Xenobiotica
; 44(8): 722-33, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24533630
7.
Effect of Saccharolactone on CYP-mediated Metabolism of Xenobiotics.
Drug Metab Bioanal Lett
; 16(2): 121-132, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37612873
8.
An inhibitor of RORγ for chronic pulmonary obstructive disease treatment.
Sci Rep
; 12(1): 8744, 2022 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35610240
9.
In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data.
Drug Metabol Drug Interact
; 23(3-4): 329-50, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19326776
10.
Studies of the macroscopic and microscopic morphology (hippocampus) of brain in Vencobb broiler.
Vet World
; 9(5): 507-11, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27284228
11.
Utility of a column-switching LC/MS/MS method in cytochrome P450 inhibition assays using human liver microsomes.
Drug Metabol Drug Interact
; 28(3): 177-85, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23729559